QIAGEN CLC LightSpeed Module

QIAGEN CLC LightSpeed Module provides an all-in-one, ultra-fast NGS analysis solution for hereditary and somatic resequencing. LightSpeed takes raw Fastq files and performs quality trimming, adapter trimming, read mapping, deduplication, local realignment, UMI grouping, primer trimming, QC and germline or somatic (tumor-only or tumor-normal) variant calling in one end-to-end solution. LightSpeed is optimized for paired-end short-read sequencing data. It is compatible with any reference sequence and supports variant detection in data from polyploid organisms.

QIAGEN CLC LightSpeed Module contains the “LightSpeed Fastq to Germline Variants”, “LightSpeed Fastq to Somatic Variants” and “LightSpeed Fastq to Somatic Variants Tumor Normal” tools which can output a read mapping, a variant track, an inversion track and a QC report, enabling a thorough assessment of sample and variant qualities. In addition, the tool Copy Number Variant Detection (WGS) is available which enables copy number variant (CNV) detection in whole genome sequencing (WGS) data without the use of controls (Figure 1). CNV detection is supported for both germline and somatic applications including automatic estimation of purity and ploidy (Figure 2).

QIAGEN CLC LightSpeed Module also provides template workflows that make use of these tools to help you analyze WGS, whole exome sequencing and targeted data. In addition, template workflows providing support for QIAseq Targeted DNA and Targeted DNA Pro panels are available (Figure 3). These workflows provide functionality for annotating variants, extended QC, creating copy number controls, CNV detection and additional visualization features.

Figure 1. Tools provided by QIAGEN CLC LightSpeed Module.
Figure 2. Genome-wide overview of CNVs identified from WGS data with QIAGEN CLC LightSpeed Module.
Figure 3. Workflows provided by QIAGEN CLC LightSpeed Module.

Learn more about the latest improvements to QIAGEN CLC LightSpeed Module.

Downloads
Plugin Manual
Plugin Download
Server Plugin Download
Sample to Insight
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